The first five matches also see the Reds take on Portsmouth, Manchester City and Tottenham, before Sir Alex goes head-to-head with Roy Keane for the first time as manager of Sunderland on 1 September.
United's run-in could be tricky, with home matches against Liverpool and Arsenal, and away trips to Middlesbrough, Blackburn and Chelsea in the last eight games.
Here are the fixtures in full:
AugustSat Aug 11 Reading (H)Tue Aug 14 Portsmouth (A)Sat Aug 18 Manchester City (A)Sat Aug 25 Tottenham Hotspur (H)
SeptemberSat Sep 1 Sunderland (H)Sat Sep 15 Everton (A)Sat Sep 22 Chelsea (H)Sat Sep 29 Birmingham City (A)
写真： Manchester United Ltd、 Getty Images